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Botulinum Toxin for the Management of Tinnitus: A Systematic Review of Human Studies

2025/11/21 by Cankaya, Abdulkadir Burak, Erdem, Mehmet Ali, Basak Keskin Yalcin +1
#Medicine and Health Sciences #botulinum toxin #hemifacial spasm #intratympanic injection #middle ear myoclonus #neuromodulation #tinnitus

paper · doi:10.17605/osf.io/tbw74

Abstract

PubMed and Scopus were searched (2015–2025) using predefined keywords: (botulinum neurotoxin OR botulinum toxin OR botox) AND tinnitus. Human studies, English language, and original clinical research were included. Reviews, case reports, animal studies, and studies without tinnitus outcomes after BTX were excluded. Data extraction included tinnitus type, BTX type/dose, injection site, outcome measures, follow-up, and adverse events. Due to heterogeneity, narrative synthesis was performed.

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