2019/05/10 by Japan K. Patel, Patel, Japan K., Richard Vasques +3 · 1 citation
Biochemistry, Genetics and Molecular Biology · #FOS: Biological sciences #Tissues and Organs (q-bio.TO) #q-bio.TO
paper · pdf · doi:10.48550/arxiv.1905.10441
10 pages, 3 figures, submitted to ANS Topical Meeting
arxiv created 2019/07/03 · arxiv updated 2019/07/05
We develop a multiphysics-based model to predict the response of localized tumors to combined-hyperthermia-radiotherapy (CHR) treatment. This procedure combines hyperthermia (tumor heating) with standard radiotherapy to improve efficacy of the overall treatment. In addition to directly killing tumor cells, tumor heating amends several parameters within the tumor microenvironment. This leads to radiosensitization, which improves the performance of radiotherapy while reducing the side-effects of excess radiation in the surrounding normal tissue. Existing tools to model this kind of treatment consider each of the physics separately. The model presented in this paper accounts for the synergy between hyperthermia and radiotherapy providing a more realistic and holistic approach to simulate CHR treatment. Our model couples radiation transport and heat-transfer with cell population dynamics.