2021/05/19 by Peter Mortensen, Noor Aziz, Mortensen, Peter +5
Engineering · Medicine · #Cardiac electrophysiology and arrhythmias #ECG Monitoring and Analysis #Electrostatic Discharge in Electronics #FOS: Biological sciences #Quantitative Methods (q-bio.QM) #Tissues and Organs (q-bio.TO)
paper · pdf · doi:10.48550/arxiv.2105.09112
openalex publication_date 2021/05/19 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28
We report three-dimensional and time-dependent numerical simulations of the propagation of electrical action potentials in a model of rabbit ventricular tissue. The simulations are performed using a finite-element method for the solution of the monodomain equations of cardiac electrical excitation. The parameters of a detailed ionic ventricular cell model are re-fitted to available experimental data and the model is then used for the description of the transmembrane current and calcium dynamics. A region with reduced conductivity is introduced to model a myocardial infarction scar. Electrical activation times and density maps of the transmembrane voltage are computed and compared with experimental measurements in rabbit preparations with myocardial infarction obtained by a panoramic optical mapping method.