2025/09/03 by Lorenzo Talamanca, Talamanca, Lorenzo, Julian Trouillon +1
Biochemistry, Genetics and Molecular Biology · Medicine · #Advanced Biosensing Techniques and Applications #FOS: Computer and information sciences #Information Theory (cs.IT) #Monoclonal and Polyclonal Antibodies Research #SARS-CoV-2 detection and testing
paper · pdf · doi:10.48550/arxiv.2509.03481
openalex publication_date 2025/09/03 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/31
Combinatorial group testing reduces screening costs and turnaround time but remains challenging to apply due to design complexity, varying applicability, and lack of implementation tools. Here we present PoolPy, a unified end-to-end framework and web platform to benchmark, automate and decode combinatorial group testing strategies tailored to application-specific constraints across assay modalities. We demonstrate PoolPy utility for protein-ligand interaction screening and genome-wide molecular profiling, enabling the scaling up of multi-readout functional assays.