2021/11/17 by Rouviere, Eric, Ranganathan, Rama, Rivoire, Olivier · 1 citation
#Biomolecules (q-bio.BM) #FOS: Biological sciences #Populations and Evolution (q-bio.PE)
paper · doi:10.48550/arxiv.2111.09377
Several physical mechanisms have been proposed to explain allostery in proteins. They differ by the number of internal states that they assume a protein to occupy, leaving open the question of what controls the emergence of these distinct physical forms of allostery. Here, we analyze a simplified model of protein allostery under a range of physical and evolutionary constraints. We find that two archetypal mechanisms can emerge through evolution: a single-state mechanism where ligand binding induces a displacement along a soft normal mode or a multi-state mechanism where ligand binding induces a switch across an energy barrier to a different stable state. Importantly, whenever the two mechanisms are possible, the multi-state mechanism confers a stronger allosteric effect and thus a selective advantage. This work defines the essential constraints on single or multi-state allostery, and sets the stage for a physical theory of its evolutionary origins.