2018/10/31 by Trang Ngoc Cao, Cao, Trang Ngoc, Arman Ahmadzadeh +11 · 1 citation
Biochemistry, Genetics and Molecular Biology · Engineering · #Advanced biosensing and bioanalysis techniques #FOS: Electrical engineering #FOS: Physical sciences #Medical Physics (physics.med-ph) #Molecular Communication and Nanonetworks #Signal Processing (eess.SP) #electronic engineering #information engineering
paper · pdf · doi:10.48550/arxiv.1811.00417
openalex publication_date 2018/10/31 · openalex created_date 2022/08/02 · openalex updated_date 2026/07/28
Nanoparticle drug carriers play an important role in facilitating efficient\ntargeted drug delivery, i.e., improving treatment success and reducing drug\ncosts and side effects. However, the mobility of nanoparticle drug carriers\nposes a challenge in designing drug delivery systems. Moreover, healing results\ncritically depend on the rate and time duration of drug absorption. Therefore,\nin this paper, we aim to design a controlled-release drug delivery system with\na mobile drug carrier that minimizes the total amount of released drugs while\nensuring a desired rate of drug absorption during a prescribed time period. We\nmodel the mobile drug carrier as a mobile transmitter, the targeted diseased\ncells as an absorbing receiver, and the channel between the transceivers as a\ntime-variant channel since the carrier mobility results in a time-variant\nabsorption rate of the drug molecules. Based on this, we develop a molecular\ncommunication (MC) framework to design the controlled-release drug delivery\nsystem. In particular, we develop new analytical expressions for the mean,\nvariance, probability density function, and cumulative distribution function of\nthe channel impulse response (CIR). Equipped with the statistical analysis of\nthe CIR, we design and evaluate the performance of the controlled-release drug\ndelivery system. Numerical results show significant savings in the amount of\nreleased drugs compared to a constant-release rate design and reveal the\nnecessity of accounting for drug carrier mobility for reliable drug delivery.\n