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Recognizing Dementia from Neuropsychological Tests with State Space Models

2025/07/14 by Liming Wang, Wang, Liming, Saurabhchand Bhati +7
Computer Science · #Artificial Intelligence (cs.AI) #Bayesian Modeling and Causal Inference #FOS: Computer and information sciences #Machine Learning (cs.LG) #Machine Learning in Healthcare

paper · pdf · doi:10.48550/arxiv.2507.10311

openalex publication_date 2025/07/14 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28

Abstract

Early detection of dementia is critical for timely medical intervention and improved patient outcomes. Neuropsychological tests are widely used for cognitive assessment but have traditionally relied on manual scoring. Automatic dementia classification (ADC) systems aim to infer cognitive decline directly from speech recordings of such tests. We propose Demenba, a novel ADC framework based on state space models, which scale linearly in memory and computation with sequence length. Trained on over 1,000 hours of cognitive assessments administered to Framingham Heart Study participants, some of whom were diagnosed with dementia through adjudicated review, our method outperforms prior approaches in fine-grained dementia classification by 21%, while using fewer parameters. We further analyze its scaling behavior and demonstrate that our model gains additional improvement when fused with large language models, paving the way for more transparent and scalable dementia assessment tools. Code: https://anonymous.4open.science/r/Demenba-0861

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