2006/03/29 by Niko Beerenwinkel, Beerenwinkel, Niko, Lior Pachter +3 · 2 citations
Biochemistry, Genetics and Molecular Biology · Economics, Econometrics and Finance · Environmental Science · Mathematics · Psychology · #Combinatorics (math.CO) #FOS: Biological sciences #FOS: Mathematics #Physical education and sports games research #Populations and Evolution (q-bio.PE) #Sports Analytics and Performance #Wildlife Ecology and Conservation #math.CO #q-bio.PE
paper · pdf · doi:10.48550/arxiv.q-bio/0603034
31 pages, 7 figures; typos removed, Example 3.10 added
openalex publication_date 2006/03/29 · arxiv created 2006/04/14 · arxiv updated 2009/12/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28
The relationship between the shape of a fitness landscape and the underlying gene interactions, or epistasis, has been extensively studied in the two-locus case. Gene interactions among multiple loci are usually reduced to two-way interactions. We present a geometric theory of shapes of fitness landscapes for multiple loci. A central concept is the genotope, which is the convex hull of all possible allele frequencies in populations. Triangulations of the genotope correspond to different shapes of fitness landscapes and reveal all the gene interactions. The theory is applied to fitness data from HIV and Drosophila melanogaster. In both cases, our findings refine earlier analyses and reveal previously undetected gene interactions.