2019/10/15 by Jens Gläser, Glaser, Jens, Sharon C. Glotzer +1
Agricultural and Biological Sciences · Chemistry · Materials Science · #Biological Physics (physics.bio-ph) #Chemical Physics (physics.chem-ph) #Computational Physics (physics.comp-ph) #FOS: Physical sciences #Liquid Crystal Research Advancements #Proteins in Food Systems #Soft Condensed Matter (cond-mat.soft) #Surfactants and Colloidal Systems
paper · pdf · doi:10.48550/arxiv.1910.06865
openalex publication_date 2019/10/15 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28
In view of the notorious complexity of protein--protein interactions, simplified models of proteins treated as patchy particles offer a promising strategy to obtain insight into the mechanism of crystallization. Here we report liquid--liquid phase separation (LLPS) with a highly asymmetric coexistence region in a computational model of rubredoxin with real molecular shape. The coexistence region terminates in both an upper (UCST) and a lower (LCST) critical solution temperature, and the complex molecular shape explains the closed-loop behavior of the LLPS.