2024/03/28 by Baris Imre, Imre, Baris, Elina Thibeau–Sutre +7
Medicine · #Computer Vision and Pattern Recognition (cs.CV) #Epilepsy research and treatment #FOS: Computer and information sciences #FOS: Electrical engineering #Image and Video Processing (eess.IV) #Neurosurgical Procedures and Complications #Traumatic Brain Injury and Neurovascular Disturbances #electronic engineering #information engineering
paper · pdf · doi:10.48550/arxiv.2403.19415
openalex publication_date 2024/03/28 · openalex created_date 2024/03/30 · openalex updated_date 2026/07/28
Chronic subdural hematoma (cSDH) is a common neurological condition characterized by the accumulation of blood between the brain and the dura mater. This accumulation of blood can exert pressure on the brain, potentially leading to fatal outcomes. Treatment options for cSDH are limited to invasive surgery or non-invasive management. Traditionally, the midline shift, hand-measured by experts from an ideal sagittal plane, and the hematoma volume have been the primary metrics for quantifying and analyzing cSDH. However, these approaches do not quantify the local 3D brain deformation caused by cSDH. We propose a novel method using anatomy-aware unsupervised diffeomorphic pseudo-healthy synthesis to generate brain deformation fields. The deformation fields derived from this process are utilized to extract biomarkers that quantify the shift in the brain due to cSDH. We use CT scans of 121 patients for training and validation of our method and find that our metrics allow the identification of patients who require surgery. Our results indicate that automatically obtained brain deformation fields might contain prognostic value for personalized cSDH treatment. Our implementation is available on: github.com/Barisimre/brain-morphing