Optimal control of crystallization of alpha-lactose monohydrate

2013/05/05 by Amira Rachah, Dominikus Noll, Rachah, Amira +5
Biochemistry, Genetics and Molecular Biology · Engineering · Materials Science · #Advanced Control Systems Optimization #Enzyme Structure and Function #FOS: Mathematics #Microbial Metabolic Engineering and Bioproduction #Optimization and Control (math.OC)

paper · doi:10.48550/arxiv.1305.1043

openalex publication_date 2013/05/05 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28

Abstract

We present a mathematical model for solvated crystallization of alpha -lactose monohydrate in semi-batch mode. The process dynamics are governed by conservation laws including population, molar and energy balance equations. We present and discuss the model and then control the process with the goal to privilege the production of small particles in specific the range. We compare several specific and unspecific cost functions leading to optimal strategies with significantly different effects on product quality. Control inputs are temperature, feed rate, and the choice of an appropriate crystal seed.

Citations

• SNOPT: An SQP Algorithm for Large-Scale Constrained Optimization
• On the implementation of an interior-point filter line-search algorithm for large-scale nonlinear programming

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