1987/11/01 by J G Dorea, José G. Dórea, J M Costa +7
Agricultural and Biological Sciences · Medicine · Biochemistry, Genetics and Molecular Biology · #Insect and Pesticide Research #Vitamin D Research Studies #Heat shock proteins research
paper · pdf · doi:10.1093/clinchem/33.11.2081
We used instrumental neutron activation analysis (INAA) to determine antimony in small quantities of hair from individuals living in an area of endemic leishmaniasis. The groups studied were 12 patients undergoing treatment with N-methylglucamine antimoniate, 34 patients who had received such treatment a year ago, and 17 control subjects (untreated) who were living in the same area. Patients receiving treatment showed mean and median (12.13, 2.9 micrograms/g) values for antimony in hair that significantly exceeded those in either controls (1.01, 0.4 microgram/g) or patients one year after treatment (1.54, 1.0 microgram/g). We conclude that INAA can be useful in monitoring and differentiating such exposure to antimony in patients under treatment.