1994/12/01 by T Kouri, Timo Kouri, V Kairisto +14 · 73 citations
Mathematics · Medicine · #Clinical Laboratory Practices and Quality Control #Computer science #Hemodynamic Monitoring and Therapy #Mathematics #Medical physics #Medicine #Statistics
paper · doi:10.1093/clinchem/40.12.2209
published in Clinical Chemistry 40(12), 2209-2215 (American Association for Clinical Chemistry)
openalex publication_date 1994/12/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/30
We utilized the databases of a hospital information system to select for determination of reference values various individual hospitalized patients on the basis of their diagnoses at discharge. The nonparametric 2.5-97.5% "health-related" reference intervals were calculated for hemoglobin concentration, mean corpuscular volume (MCV), and erythrocyte count for both sexes. After excluding patients with diseases possibly affecting erythrocyte variables, we obtained a final group of 1786 women and 1450 men, ages 20-65 years, who were studied in age groups of 20-30, 30-45, 45-55, and 55-65 years. The upper reference limits of the MCV results obtained from hospitalized patients were higher than those produced conventionally from healthy individuals, as would be intuitively suggested by clinical experience. This method, based on selection by diagnosis, could be applicable to various analytes measured in hospital laboratories, provided sufficient data are available as databases.