Label-free optical quantification of structural alterations in\n Alzheimer's disease

2016/03/02 by Moosung Lee, Lee, Moosung, Eek‐Sung Lee +13
Biochemistry, Genetics and Molecular Biology · Medicine · #Advanced Fluorescence Microscopy Techniques #Cell Image Analysis Techniques #FOS: Physical sciences #Medical Physics (physics.med-ph) #Optical Imaging and Spectroscopy Techniques

paper · pdf · doi:10.48550/arxiv.1603.00698

openalex publication_date 2016/03/02 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28

Abstract

We present a quantitative label-free imaging of mouse whole brain tissue\nslices with sub-micrometre resolution, employing holographic microscopy and an\nautomated scanning platform. From the measured light field images, scattering\ncoefficients and anisotropies are quantitatively retrieved, which enables\naccess to structural information about brain tissues. As a proof of principle,\nwe demonstrate that these scattering parameters enable us to quantitatively\naddress structural alteration in the brain tissues of mice with Alzheimer's\ndisease.\n

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