A global multicenter study on reference values: 2. Exploration of sources of variation across the countries

2016/09/23 by Kiyoshi Ichihara, Yeşim Özarda, Yesim Ozarda +20 · 12 citations
Medicine · Agricultural and Biological Sciences · #Clinical Laboratory Practices and Quality Control #Diabetes, Cardiovascular Risks, and Lipoproteins #Pesticide Residue Analysis and Safety

paper · doi:10.1016/j.cca.2016.09.015

Abstract

OBJECTIVES: The intent of this study, based on a global multicenter study of reference values (RVs) for serum analytes was to explore biological sources of variation (SVs) of the RVs among 12 countries around the world. METHODS: ). RESULTS: , BMI related changes were observed for many nutritional and inflammatory markers in almost all countries. However, the slope of linear regression of BMI vs. RV differed greatly among countries for some analytes. Alcohol and smoking-related changes were observed less conspicuously in a limited number of analytes. CONCLUSION: The features of sex, age, alcohol, and smoking-related changes in RVs of the analytes were largely comparable worldwide. The finding of differences in BMI-related changes among countries in some analytes is quite relevant to understanding ethnic differences in susceptibility to nutritionally related diseases.

Cited by

• A global multicenter study on reference values: 1. Assessment of methods for derivation and comparison of reference intervals
• Indirect Reference Intervals: Harnessing the Power of Stored Laboratory Data. [europepmc]
• Determination of reference intervals for common chemistry and immunoassay tests for Kenyan adults based on an internationally harmonized protocol and up-to-date statistical methods. [europepmc]
• Establishing Ghanaian adult reference intervals for hematological parameters controlling for latent anemia and inflammation. [europepmc]
• Sources of variation and establishment of Russian reference intervals for major hormones and tumor markers. [europepmc]
• Establishment of reference intervals of clinical chemistry analytes for the adult population in Egypt. [europepmc]
• Current State of Pediatric Reference Intervals and the Importance of Correctly Describing the Biochemistry of Child Development: A Review. [europepmc]
• Region-specific laboratory reference intervals are important: A systematic review of the data from Africa. [europepmc]
• Unsupervised machine learning method for indirect estimation of reference intervals for chronic kidney disease in the Puerto Rican population. [europepmc]
• Serum reference intervals of micronutrients, vitamins, and interleukins among healthy adults in South-Western Nigeria. [europepmc]
• Derivation of Russian-specific reference intervals for complete blood count, iron markers and related vitamins. [europepmc]
• Extended Roles in Healthcare Delivery: What Is the Role of the Laboratory in Addressing Ethnicity-Related Healthcare Disparities? [europepmc]
• Data-driven age partitioning for pediatric serum copper: implications for reference interval interpretation. [europepmc]

Related

• A global multicenter study on reference values: 1. Assessment of methods for derivation and comparison of reference intervals
• Similarity Analysis of Complete Blood Count (CBC) Reference Interval Distributions Across Ethnic and Geographic Populations
• A comparison of deep multiomics profiles across ethnicity, geography, and age
• Biological Variation Estimates Obtained from 91 Healthy Study Participants for 9 Enzymes in Serum
• Estimates of Within-Subject Biological Variation Derived from Pathology Databases: An Approach to Allow Assessment of the Effects of Age, Sex, Time between Sample Collections, and Analyte Concentration on Reference Change Values