The Structural Factor of Hypertension
2015/03/12 by Stéphane Laurent, Pierre Boutouyrie · 29 citations
Medicine · #Cardiovascular Health and Disease Prevention #Blood Pressure and Hypertension Studies #Cerebrovascular and Carotid Artery Diseases
paper · doi:10.1161/circresaha.116.303596
Abstract
Pathophysiological studies have extensively investigated the structural factor in hypertension, including large and small artery remodeling and functional changes. Here, we review the recent literature on the alterations in small and large arteries in hypertension. We discuss the possible mechanisms underlying these abnormalities and we explain how they accompany and often precede hypertension. Finally, we propose an integrated pathophysiological approach to better understand how the cross-talk between large and small artery changes interacts in pressure wave transmission, exaggerates cardiac, brain and kidney damage, and lead to cardiovascular and renal complications. We focus on patients with essential hypertension because this is the most prevalent form of hypertension, and describe other forms of hypertension only for contrasting their characteristics with those of uncomplicated essential hypertension.
Citations
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