2007/08/12 by Chiu Fan Lee, Lee, Chiu Fan
Physics and Astronomy · #FOS: Physical sciences #Materials Science (cond-mat.mtrl-sci) #Soft Condensed Matter (cond-mat.soft) #cond-mat.mtrl-sci #cond-mat.soft
paper · pdf · doi:10.48550/arxiv.0708.1632
arxiv created 2008/08/03 · arxiv updated 2009/12/01
We study the two-filament insulin fibril's structure by incorporating recent simulation results and mechanical measurements. Our investigation suggests that the persistence length measurement correlates well with the previously proposed structural model, while the elasticity measurement suggests that stretching the fibril may involve hydrogen bond breakage. Our work illustrates an attempt to correlate nanoscale measurements with microscopic information on the quaternary protein structure.