2020/01/10 by Marta Bofill Roig, Roig, Marta Bofill, Jordi Cortés Martínez +3
Decision Sciences · Economics, Econometrics and Finance · Mathematics · #Applications (stat.AP) #Computation (stat.CO) #FOS: Computer and information sciences #Health Systems, Economic Evaluations, Quality of Life #Meta-analysis and systematic reviews #Statistical Methods in Clinical Trials #stat.AP #stat.CO
paper · pdf · doi:10.48550/arxiv.2001.03396
arxiv created 2020/01/10 · openalex publication_date 2020/01/10 · arxiv updated 2020/01/13 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28
Summary points: - This article considers the combination of two binary or two time-to-event endpoints to form the primary composite endpoint for leading a trial. - It discusses the relative efficiency of choosing a composite endpoint over one of its components in terms of: the frequencies of observing each component; the relative treatment effect of the tested therapy; and the association between both components. - We highlight the very important role of the association between components in choosing the most efficient endpoint to use as primary. - For better grounded future trials, we recommend trialists to always reporting the association between components of the composite endpoint. - Common fallacies to note when using composite endpoints: i) composite endpoints always imply higher power; ii) treatment effect on the composite endpoint is similar to the average effects of its components; and iii) the probability of observing the primary endpoint increases significantly.