Inflammation Resolution: Implications for Atherosclerosis

2022/01/07 by Amanda C. Doran · 158 citations
Immunology and Microbiology · #Atherosclerosis and Cardiovascular Diseases #Immune cells in cancer #Immune system #Inflammation #Mediator #Phagocytosis and Immune Regulation #Proinflammatory cytokine #Resolution (logic)

paper · pdf · doi:10.1161/circresaha.121.319822

published in Circulation Research 130(1), 130-148 (Lippincott Williams & Wilkins)

openalex publication_date 2022/01/07 · openalex created_date 2022/01/25 · openalex updated_date 2026/08/01

Abstract

Resolution is an active and highly coordinated process that occurs in response to inflammation to limit tissue damage and promote repair. When the resolution program fails, inflammation persists. It is now understood that failed resolution is a major underlying cause of many chronic inflammatory diseases. Here, we will review the major failures of resolution in atherosclerosis, including the imbalance of proinflammatory to pro-resolving mediator production, impaired clearance of dead cells, and functional changes in immune cells that favor ongoing inflammation. In addition, we will briefly discuss new concepts that are emerging as possible regulators of resolution and highlight the translational significance for the field.

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