Age-Related Changes in Glucose Metabolism, Hyperglycemia, and Cardiovascular Risk
2018/09/13 by Chee W. Chia, Josephine M. Egan, Luigi Ferrucci · 31 citations
Medicine · Biochemistry, Genetics and Molecular Biology · #Diabetes, Cardiovascular Risks, and Lipoproteins #Diabetes Treatment and Management #Metabolism, Diabetes, and Cancer
paper · pdf · doi:10.1161/circresaha.118.312806
Abstract
Aging and diabetes mellitus are 2 well-known risk factors for cardiovascular disease (CVD). During the past 50 years, there has been an dramatic increase in life expectancy with a simultaneous increase in the prevalence of diabetes mellitus in the older population. This large number of older individuals with diabetes mellitus is problematic given that CVD risk associated with aging and diabetes mellitus. In this review, we summarize epidemiological data relating to diabetes mellitus and CVD, with an emphasis on the aging population. We then present data on hyperglycemia as a risk factor for CVD and review the current knowledge of age-related changes in glucose metabolism. Next, we review the role of obesity in the pathogenesis of age-related glucose dysregulation, followed by a summary of the results from major randomized controlled trials that focus on cardiovascular risk reduction through glycemic control, with a special emphasis on older adults. We then conclude with our proposed model of aging that body composition changes and insulin resistance link possible dysregulation of physiological pathways leading to obesity and diabetes mellitus-both forms of accelerated aging-and risks for CVD.
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