Harmonizing the Metabolic Syndrome
2009/10/05 by K. G. M. M. Alberti, K.G.M.M. Alberti, Robert H. Eckel +11 · 14,806 citations
Medicine · #Abdominal obesity #Blood pressure #Diabetes mellitus #Diabetes, Cardiovascular Risks, and Lipoproteins #Diet, Metabolism, and Disease #Dyslipidemia #Endocrinology #Internal medicine #Medicine #Metabolic syndrome #Obesity #Pharmacology and Obesity Treatment #Waist
paper · pdf · doi:10.1161/circulationaha.109.192644
published in Circulation 120(16), 1640-1645 (Lippincott Williams & Wilkins)
openalex publication_date 2009/10/05 · openalex created_date 2016/06/24 · openalex updated_date 2026/08/05
Abstract
A cluster of risk factors for cardiovascular disease and type 2 diabetes mellitus, which occur together more often than by chance alone, have become known as the metabolic syndrome. The risk factors include raised blood pressure, dyslipidemia (raised triglycerides and lowered high-density lipoprotein cholesterol), raised fasting glucose, and central obesity. Various diagnostic criteria have been proposed by different organizations over the past decade. Most recently, these have come from the International Diabetes Federation and the American Heart Association/National Heart, Lung, and Blood Institute. The main difference concerns the measure for central obesity, with this being an obligatory component in the International Diabetes Federation definition, lower than in the American Heart Association/National Heart, Lung, and Blood Institute criteria, and ethnic specific. The present article represents the outcome of a meeting between several major organizations in an attempt to unify criteria. It was agreed that there should not be an obligatory component, but that waist measurement would continue to be a useful preliminary screening tool. Three abnormal findings out of 5 would qualify a person for the metabolic syndrome. A single set of cut points would be used for all components except waist circumference, for which further work is required. In the interim, national or regional cut points for waist circumference can be used.
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