2025/01/01 by Hartwig, Andrea, MAK Commission
Biochemistry, Genetics and Molecular Biology · Environmental Science · Medicine · #571.95 Toxicology #571.95 Toxikologie #616.9803 Betriebs- und Arbeitsmedizin #616.9803 Industrial and occupational medicine #Aminobenzene #Aminobenzol #Anilin #Aniline #Carcinogens and Genotoxicity Assessment #Hautresorption #Indoor Air Quality and Microbial Exposure #Kanzerogenität #Luft #MAK value #MAK-Wert #Methämoglobin #Occupational exposure and asthma #Phenylamin #Phenylamine #Sensibilisierung #Spitzenbegrenzung #air #carcinogenicity #maximale Arbeitsplatzkonzentration #maximum workplace concentration #methaemoglobin #peak limitation #sensitization #skin absorption
paper · doi:10.34865/mb5263d0064_w
openalex publication_date 2025/01/01 · openalex created_date 2025/12/13 · openalex updated_date 2026/07/01
The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has re‐evaluated the maximum concentration at the workplace (MAK value) for aniline [62‐53‐3]. Available publications and unpublished study reports are described in detail. Healthy male and female volunteers showed increased methemoglobin values in a 6‐hour‐inhalation‐study with exposure to 2 ml aniline/m3. The median methemoglobin augmentation was 0.5 % from the base level of 0.7 % to 1.2 % methemoglobin. Even taking into account the highest observed increase of methemoglobin, 8 hour‐exposure time and the increased respiratory volume at the workplace, a methemoglobin value of more than 5 % would not be expected. Based on this, the MAK value for aniline of 2 ml/m3 (7.7 mg/m3) is confirmed. Aniline is still assigned to Peak Limitation Category II, because systemic effects are critical and the excursion factor of 2 is confirmed. Skin contact is expected to contribute significantly to the systemic toxicity. Therefore, the designation with an “H” is confirmed. Aniline continues to be designated with “Sh” and assigned to Carcinogenicity Category 4.