2025/01/01 by Bolt, Hermann Maximilian, Drexler, Hans, Hartwig, Andrea +1
Biochemistry, Genetics and Molecular Biology · Medicine · #Carcinogens and Genotoxicity Assessment #Occupational exposure and asthma #Occupational and environmental lung diseases
paper · doi:10.34865/bb12718d0023_w
In 2017, the German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has re‐evaluated tetrachloroethylene [CAS No. 127‐18‐4] considering tetrachloroethylene in blood to characterize the internal exposure at the workplace. Available publications are described in detail. The exposure equivalents for carcinogenic substances (EKA) of tetrachloroethylene uptake by inhalation and tetrachloroethylene in blood were confirmed and extended due to recent data. The evaluation of the BAT value was based on the relationship between tetrachloroethylene uptake by inhalation at the MAK value and the corresponding concentration of tetrachloroethylene in blood. An eight‐hour exposure to the present MAK value of 10 ml tetrachloroethylene/m3 correlates 16 hours after exposure with a mean tetrachloroethylene concentration in blood of approximately 200 µg/l. Therefore, a BAT value of 200 µg tetrachloroethylene/l blood was evaluated. Sampling time is 16 hours after exposure.