Hidden complexities in the unfolding mechanism of a cytosine-rich DNA strand

2011/09/26 by Jens Smiatek, Smiatek, Jens, Daniel Janssen-Mueller +5
Biochemistry, Genetics and Molecular Biology · Physics and Astronomy · #Biological Physics (physics.bio-ph) #Biomolecules (q-bio.BM) #Computational Physics (physics.comp-ph) #FOS: Biological sciences #FOS: Physical sciences #Soft Condensed Matter (cond-mat.soft) #cond-mat.soft #physics.bio-ph #physics.comp-ph #q-bio.BM

paper · pdf · doi:10.48550/arxiv.1109.5474

5 pages, 5 figures

arxiv created 2011/09/26 · arxiv updated 2011/09/27

Abstract

We investigate the unfolding pathway of a cytosine-rich DNA hairpin structure via Molecular Dynamics simulations. Our results indicate a hidden complexity present in the unfolding process. W e show that this complex behavior arises due to non-stochastic contributions which have an important impact on the description of the dynamics in terms of collective variables.

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