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Youth Engagement in HPV Vaccine Behavioral Clinical Trials: A Cross-Sectional Global Registry Review from 2006-2025

2025/12/01 by Nouran Ghonaim, Whaley, Megan, Jutamas Suwannawat +1
#Adolescent engagement #HPV #Human Papillomavirus #Medicine and Health Sciences #Participatory Action Research #Systematic Review #Trial registry #Vaccination

paper · doi:10.17605/osf.io/prw56

Abstract

Human papillomavirus (HPV), the most common sexually transmitted infection globally, causes six cancers and costs 9.01 billion annually for HPV‑related diseases in the United States. Despite the vaccine’s proven safety and recommendation for adolescents aged 11–12, coverage remains low. Behavioral trials that meaningfully engage adolescents offer a critical strategy to improve vaccine acceptance, uptake, and ultimately reduce the long‑term health and economic burden of HPV. This study examined how adolescents have been engaged in behavioral intervention trials aimed at increasing HPV vaccination uptake or intention.

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