2025/01/15 by Richard Foster, Foster, Richard R., Laura Ellwein Fix +1
Engineering · Medicine · #92-10 #92C35 #FOS: Biological sciences #Neonatal Respiratory Health Research #Non-Invasive Vital Sign Monitoring #Respiratory Support and Mechanisms #Tissues and Organs (q-bio.TO)
paper · pdf · doi:10.48550/arxiv.2501.08533
openalex publication_date 2025/01/15 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28
The complexity of mathematical models describing respiratory mechanics has grown in recent years, however, parameter identifiability of such models has only been studied in the last decade in the context of observable data. This study investigates parameter identifiability of a nonlinear respiratory mechanics model tuned to the physiology of an extremely preterm infant, using global Morris screening, local deterministic sensitivity analysis, and singular value decomposition-based subset selection. The model predicts airflow and dynamic pulmonary volumes and pressures under varying levels of continuous positive airway pressure, and a range of parameters characterizing both surfactant-treated and surfactant-deficient lung. Sensitivity analyses indicated eleven parameters influence model outputs over the range of continuous positive airway pressure and lung health scenarios. The model was adapted to data from a spontaneously breathing 1 kg infant using gradient-based optimization to estimate the parameter subset characterizing the patient's state of health.