2016/01/25 by Koyel Chakravarty, Chakravarty, Koyel, D. C. Dalal +1
Agricultural and Biological Sciences · Biochemistry, Genetics and Molecular Biology · Pharmacology, Toxicology and Pharmaceutics · #Biological Physics (physics.bio-ph) #Drug Solubulity and Delivery Systems #Dynamical Systems (math.DS) #FOS: Biological sciences #FOS: Mathematics #FOS: Physical sciences #Polysaccharides Composition and Applications #Protein purification and stability #Tissues and Organs (q-bio.TO)
paper · pdf · doi:10.48550/arxiv.1601.06485
openalex publication_date 2016/01/25 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28
Local drug delivery has received much recognition in recent years, yet it is still unpredictable how drug efficacy depends on physicochemical properties and delivery kinetics. The purpose of the current study is to provide a useful mathematical model for drug release from a drug delivery device and consecutive drug transport in biological tissue, thereby aiding the development of new therapeutic drug by a systemic approach. In order to study the complete process, a two-layer spatio-temporal model depicting drug transport between the coupled media is presented. Drug release is described by considering solubilisation dynamics of drug particle, diffusion of the solubilised drug through porous matrix and also some other processes like reversible dissociation / recrystallization, drug particle-receptor binding and internalization phenomena. The model has led to a system of partial differential equations describing the important properties of drug kinetics. This model contributes towards the perception of the roles played by diffusion, mass-transfer, particle binding and internalization parameters.