Global burden of heart failure: a comprehensive and updated review of epidemiology
2022/02/08 by Gianluigi Savarese, Peter Moritz Becher, Lars H. Lund +7 · 43 citations
Medicine · #Cardiovascular Function and Risk Factors #Cardiovascular and exercise physiology #Heart Failure Treatment and Management
paper · doi:10.1093/cvr/cvac013
openalex publication_date 2022/02/08 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/31
Abstract
Heart Failure (HF) is a multi-faceted and life-threatening syndrome characterized by significant morbidity and mortality, poor functional capacity and quality of life, and high costs. HF affects more than 64 million people worldwide. Therefore, attempts to decrease its social and economic burden have become a major global public health priority. While the incidence of HF has stabilized and seems to be declining in industrialized countries, the prevalence is increasing due to the ageing of the population, improved treatment of and survival with ischaemic heart disease, and the availability of effective evidence-based therapies prolonging life in patients with HF. There are geographical variations in HF epidemiology. There is substantial lack of data from developing countries, where HF exhibits different features compared with that observed in the Western world. In this review, we provide a contemporary overview on the global burden of HF, providing updated estimates on prevalence, incidence, outcomes, and costs worldwide.
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- Extracellular Vesicles, Inflammation, and Cardiovascular Disease. [europepmc]
- Sacubitril/valsartan in heart failure: efficacy and safety in and outside clinical trials. [europepmc]
- Aging and aging-related diseases: from molecular mechanisms to interventions and treatments. [europepmc]
- Association of Social Isolation and Loneliness With Incident Heart Failure in a Population-Based Cohort Study. [europepmc]
- Myocardial Metabolomics of Human Heart Failure With Preserved Ejection Fraction. [europepmc]
- Management of patients with heart failure and preserved ejection fraction. [europepmc]
- Practical guidelines for exercise prescription in patients with chronic heart failure. [europepmc]
- The application of Aptamer in biomarker discovery. [europepmc]
- The Role of Galectin-3 in Heart Failure-The Diagnostic, Prognostic and Therapeutic Potential-Where Do We Stand? [europepmc]
- Heart Failure Epidemiology and Outcomes Statistics: A Report of the Heart Failure Society of America. [europepmc]
- World Heart Federation Consensus on Transthyretin Amyloidosis Cardiomyopathy (ATTR-CM). [europepmc]
- The benefits of GLP1 receptors in cardiovascular diseases. [europepmc]
- TikTok video as a health education source of information on heart failure in China: a content analysis. [europepmc]
- Digital Health Interventions for Heart Failure Management in Underserved Rural Areas of the United States: A Systematic Review of Randomized Trials. [europepmc]
- Association between haemoglobin, albumin, lymphocytes, and platelets and mortality in patients with heart failure. [europepmc]
- Epidemiology of heart failure in diabetes: a disease in disguise. [europepmc]
- Heart failure pharmacotherapy and cancer: pathways and pre-clinical/clinical evidence. [europepmc]
- SGLT2 Inhibitors, Functional Capacity, and Quality of Life in Patients With Heart Failure: A Systematic Review and Meta-Analysis. [europepmc]
- Atrial Fibrillation Ablation in Heart Failure With Reduced vs Preserved Ejection Fraction: A Systematic Review and Meta-Analysis. [europepmc]
- 2024 update in heart failure. [europepmc]
- Mitochondrial quality control in human health and disease. [europepmc]
- DNA methylation in cardiovascular disease and heart failure: novel prediction models? [europepmc]
- Heart failure in Europe: Guideline-directed medical therapy use and decision making in chronic and acute, pre-existing and de novo, heart failure with reduced, mildly reduced, and preserved ejection fraction - the ESC EORP Heart Failure III Registry. [europepmc]
- Predicting 28-day all-cause mortality in patients admitted to intensive care units with pre-existing chronic heart failure using the stress hyperglycemia ratio: a machine learning-driven retrospective cohort analysis. [europepmc]
- Global, regional, and national burden of heart failure and its underlying causes, 1990-2021: results from the global burden of disease study 2021. [europepmc]
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