2024/10/05
paper · doi:10.17912/micropub.biology.001365
<p>During maternal reprogramming of histone methylation in <i><a href="https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&id=6239" id="85dadd30-1b89-454a-9157-d5c3cdf86e84">C. elegans</a></i>, H3K4me is removed by the histone demethylase, <a href="http://www.wormbase.org/db/get?name=WBGene00005010;class=Gene" id="5ae791f9-bbd2-4571-9048-40d7d180aa84">SPR-5</a>, and H3K9me is subsequently added by the histone methyltransferase, <a href="http://www.wormbase.org/db/get?name=WBGene00019883;class=Gene" id="e3081d97-dfc7-443c-ad14-320c0ef78e70">MET-2</a>. Maternal loss of <a href="http://www.wormbase.org/db/get?name=WBGene00005010;class=Gene" id="87be1798-7adf-43a9-96a0-d0369ce70744">SPR-5</a> and <a href="http://www.wormbase.org/db/get?name=WBGene00019883;class=Gene" id="50afc285-5522-4b84-872b-461b23c65771">MET-2</a> causes inherited phenotypes, such as sterility, in the progeny. Here, we find that knocking down either the H3K4 methyltransferase <a href="http://www.wormbase.org/db/get?name=WBGene00004782;class=Gene" id="d3f7405b-3112-4a74-8824-115bc4362d52">SET-2</a> or the H3K36 methyltransferase <a href="http://www.wormbase.org/db/get?name=WBGene00003222;class=Gene" id="db80bdb5-9990-43b0-82bb-44949bf53579">MES-4</a> partially rescues the germline in the progeny of <i><a href="http://www.wormbase.org/db/get?name=WBGene00005010;class=Gene" id="1d0311c0-2528-425f-a272-100153895446">spr-5</a>; <a href="http://www.wormbase.org/db/get?name=WBGene00019883;class=Gene" id="6e442dff-bed0-43e6-9ce9-cd945c74b258">met-2</a></i> mutants, suggesting that the inherited sterility may be caused by inherited H3K4 methylation and altered germline transcription.</p>