2020/12/18 by Padi Fuster Aguilera, Aguilera, Padi Fuster, Vincent R. Martinez +3 · 1 citation
Biochemistry, Genetics and Molecular Biology · Mathematics · Medicine · #35A01 #35A02 #35K57 #92B05 #Analysis of PDEs (math.AP) #Cancer Cells and Metastasis #FOS: Mathematics #Gene Regulatory Network Analysis #Mathematical Biology Tumor Growth
paper · pdf · doi:10.48550/arxiv.2012.10521
openalex publication_date 2020/12/18 · openalex created_date 2021/01/05 · openalex updated_date 2026/07/28
In this paper, we study the initial-boundary value problem and its asymptotic behavior for a repulsive chemotaxis model with logarithmic sensitivity and logistic growth. We establish global well-posedness of strong solutions for large initial data with Neumann boundary conditions and, moreover, establish the qualitative result that both the population density and chemical concentration asymptotically converge to constant states with the population density specifically converging to its carrying capacity. We additionally prove that the vanishing chemical diffusivity limit holds in this regime. Lastly, we provide numerical confirmation of the rigorous qualitative results, as well as numerical simulations that demonstrate a separation of scales phenomenon.