General mechanisms of metastasis

1997/10/15 by Elisa C. Woodhouse, Rodrigo F. Chuaqui, Lance A. Liotta · 26 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #Angiogenesis and VEGF in Cancer #Cancer Cells and Metastasis #Mechanisms of cancer metastasis

paper · doi:10.1002/(sici)1097-0142(19971015)80:8+<1529::aid-cncr2>3.0.co;2-f

Abstract

In the present article, the steps involved in the process of tumor metastasis are discussed. Several events are required for malignant cells to leave the primary tumor and proliferate at a distant site: vessel formation (angiogenesis), cell attachment, invasion (matrix degradation, cell motility), and cell proliferation. Molecular mechanisms underlying each of these steps are described. Based on blocking these processes, new anti-metastasis therapies are being developed.

Cited by

• Galectin-3 in angiogenesis and metastasis
• Prognostic significance of MCM2, Ki-67 and gelsolin in non-small cell lung cancer. [europepmc]
• A novel circular invasion assay mimics in vivo invasive behavior of cancer cell lines and distinguishes single-cell motility in vitro. [europepmc]
• Berberine suppresses TNF-alpha-induced MMP-9 and cell invasion through inhibition of AP-1 activity in MDA-MB-231 human breast cancer cells. [europepmc]
• Establishment and characterization of human osteosarcoma cell lines with different pulmonary metastatic potentials. [europepmc]
• Reduction of lung metastasis, cell invasion, and adhesion in mouse melanoma by statin-induced blockade of the Rho/Rho-associated coiled-coil-containing protein kinase pathway. [europepmc]
• Hypochlorite-induced oxidative stress elevates the capability of HDL in promoting breast cancer metastasis. [europepmc]
• Prognostic impact of EMT (epithelial-mesenchymal-transition)-related protein expression in endometrial cancer. [europepmc]
• Palladin regulation of the actin structures needed for cancer invasion. [europepmc]
• High calcium concentration in bones promotes bone metastasis in renal cell carcinomas expressing calcium-sensing receptor. [europepmc]
• C-X-C motif chemokine 12/C-X-C chemokine receptor type 7 signaling regulates breast cancer growth and metastasis by modulating the tumor microenvironment. [europepmc]
• Site-specific metabolic phenotypes in metastatic breast cancer. [europepmc]
• Marine bromophenol bis (2,3-dibromo-4,5-dihydroxy-phenyl)-methane inhibits the proliferation, migration, and invasion of hepatocellular carcinoma cells via modulating β1-integrin/FAK signaling. [europepmc]
• EMT and tumor metastasis. [europepmc]
• Expression of cancer-associated fibroblast related proteins in metastatic breast cancer: an immunohistochemical analysis. [europepmc]
• Expression of Lipid Metabolism-Related Proteins in Metastatic Breast Cancer. [europepmc]
• Biomarkers for EMT and MET in breast cancer: An update. [europepmc]
• Differential Site-Based Expression of Pentose Phosphate Pathway-Related Proteins among Breast Cancer Metastases. [europepmc]
• hsa-miR-485-5p reverses epithelial to mesenchymal transition and promotes cisplatin-induced cell death by targeting PAK1 in oral tongue squamous cell carcinoma. [europepmc]
• Follistatin-like 1 in development and human diseases. [europepmc]
• Interleukin-1 Beta-A Friend or Foe in Malignancies? [europepmc]
• MicroRNA in Lung Cancer Metastasis. [europepmc]
• FAM83D promotes epithelial-mesenchymal transition, invasion and cisplatin resistance through regulating the AKT/mTOR pathway in non-small-cell lung cancer. [europepmc]
• The Role of Adipokines and Bone Marrow Adipocytes in Breast Cancer Bone Metastasis. [europepmc]
• Role of Phytochemicals in Cancer Chemoprevention: Insights. [europepmc]
• Saponins in Cancer Treatment: Current Progress and Future Prospects. [europepmc]

Related

• Defining the Hallmarks of Metastasis
• The role of the organ microenvironment in the biology and therapy of cancer metastasis
• Mathematical modeling of the metastatic process
• Modeling metastasis – leveraging novel tools to streamline discovery in advanced cancer
• Interactions between cancer cells and the endothelium in metastasis