Inferring clonal composition from multiple tumor biopsies

2017/01/27 by Manica, Matteo, Kim, Hyunjae Ryan, Mathis, Roland +14
#FOS: Biological sciences #Genomics (q-bio.GN)

paper · doi:10.48550/arxiv.1701.07940

Abstract

Explicit accounting for copy number alterations can dramatically improve mutation frequency estimates, leading to more accurate phylogeny reconstructions and subclone characterizations.

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