1982/01/01 by Antonia Flaks, Bojan Flaks
Agricultural and Biological Sciences · Pharmacology, Toxicology and Pharmaceutics · #Food Quality and Safety Studies #Ginger and Zingiberaceae research
paper · doi:10.1093/carcin/3.9.981
openalex publication_date 1982/01/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/29
Male Leeds strain rats were given a diet containing either 0.06% 3'-methyl-4-dimethylaminoazobenzene (3'-MeDAB) or 0.05% 2-acetylaminofluorene (2-AAF), alone or together with 0.0067% 3-methylcholanthrene (MeCh). MeCh both reduced the incidence of hepatic neoplasms induced by 3'-MeDAB and delayed their development. With 2-AAF, however, inhibition of hepatocarcinogenesis by MeCh only appeared to operate during the period of treatment; thereafter the incidence of tumours rose rapidly and this was accentuated if dietary MeCh continued to be administered after the period of combined 2-AAF and MeCh treatment, suggesting a secondary, promoting effect of MeCH. In contrast, the inhibition by MeCh of carcinogenesis of Zymbal's gland due to 2-AAF was almost complete. Thus, in the long term MeCh has different effects upon 3'-MeDAB and 2-AAF carcinogenesis in the rat liver.