2005/12/01 by Piotr Szymczak, Szymczak, Piotr, Marek Cieplak +1
Biochemistry, Genetics and Molecular Biology · Physics and Astronomy · #Biomolecules (q-bio.BM) #FOS: Biological sciences #FOS: Physical sciences #Force Microscopy Techniques and Applications #Lipid Membrane Structure and Behavior #Protein Structure and Dynamics #Soft Condensed Matter (cond-mat.soft) #cond-mat.soft #q-bio.BM
paper · pdf · doi:10.48550/arxiv.q-bio/0512004
14 pages, 6 figures; submitted to J. Phys. Cond. Matt
arxiv created 2005/12/01 · openalex publication_date 2005/12/01 · arxiv updated 2009/12/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28
Mechanically induced protein unfolding in the force-clamp apparatus is shown, in a coarse-grained model of ubiquitin, to have lognormal statistics above a treshold force and exponential below it. Correspondingly, the mean unfolding time is slowly varying and exponentially decreases as a function of the force. The time dependencies of the end-to-end distances are also distinct. The time sequence of unfolding events weakly depends on force and much of it resembles that for stretching at constant speed. A more complicated time dependence arises for integrin.