2001/10/10 by Hans W. Moises, Moises, Hans W. M.
Biochemistry, Genetics and Molecular Biology · #Bioinformatics and Genomic Networks #Disordered Systems and Neural Networks (cond-mat.dis-nn) #FOS: Biological sciences #FOS: Physical sciences #Genetic Associations and Epidemiology #Genetics and Neurodevelopmental Disorders #Protein Structure and Dynamics #Quantitative Biology (q-bio) #Soft Condensed Matter (cond-mat.soft)
paper · pdf · doi:10.48550/arxiv.cond-mat/0110189
openalex publication_date 2001/10/10 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28
The Human Genome Project (HGP) provides researchers with the data of nearly\nall human genes and the challenge to use this information for elucidating the\netiology of common disorders. A secondary Darwinian method was applied to HGP\nand other research data to approximate and possibly unravel the etiology of\nschizophrenia. The results indicate that genetic and epigenetic variants of\ngenes involved in signal transduction, transcription and translation -\nconverging at the protein-synthesis rate (PSR) as common final pathway - might\nbe responsible for the genetic susceptibility to schizophrenia. Environmental\n(e.g. viruses)and/or genetic factors can lead to cerebral PSR (CPSR)\ndeficiency. The CPSR hypothesis of schizophrenia and antipsychotic mechanism\nexplains 96% of the major facts of schizophrenia, reveals links between\npreviously unrelated facts, integrates many hypotheses, and implies that\nschizophrenia should be easily preventable and treatable, partly by\nimmunization against neurotrophic viruses and partly by the development of new\ndrugs which selectively increase CPSR. Part of the manuscript has been\npublished in a modified form as "The glial growth factors deficiency and\nsynaptic destabilization hypothesis of schizophrenia" in BMC Psychiatry\navailable online at http://www.biomedcentral.com/1471-244X/2/8/\n