Urinary N-acetyl- beta-D-glucosaminidase activities in patients with renal disease.

1975/08/16 by J M Wellwood, B G Ellis, B.G. Ellis +8 · 12 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #Chronic Kidney Disease and Diabetes #Chronic renal disease #Creatinine #Diabetes and associated disorders #Dialysis and Renal Disease Management #Disease #Endocrinology #Internal medicine #Medicine #Renal function #Urinary system #Urine #Urology

paper · pdf · doi:10.1136/bmj.3.5980.408

openalex publication_date 1975/08/16 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28

Abstract

Urinary N-acetyl-beta-D-glucosaminidase (NAG) activities were assayed in every urine void throughout 24 hours in 17 normal people and in four patients with renal disease. The variation in NAG activity due to changing rates of urine flow was almost eliminated by factoring enzyme activity by the urinary creatinine concentration. Random samples of urine may thus be used for assay. The results of NAG assay in 36 patients with acute and chronic renal diseases showed that NAG was a sensitive indicator of renal damage. This simple test may be valuable in detecting or monitoring renal disease.

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