Controlled Sedation with Alphaxalone-Alphadolone

1974/06/22 by M. A. E. Ramsay, Michael A. E. Ramsay, T.M. Savege +5 · 28 citations
Medicine · #Anesthesia and Sedative Agents #Intensive Care Unit Cognitive Disorders #Cardiac, Anesthesia and Surgical Outcomes

paper · pdf · doi:10.1136/bmj.2.5920.656

Abstract

Alphaxalone-alphadolone (Althesin), diluted and administered as a controlled infusion, was used as a sedative for 30 patients in an intensive therapy unit. This technique allowed rapid and accurate control of the level of sedation. It had three particularly useful applications: it provided "light sleep," allowed rapid variation in the level of sedation, and enabled repeated assessment of the central nervous system.Sedation was satisfactory for 86% of the total time, and no serious complications were attributed to the use of the drug. Furthermore, though alphaxalone-alphadolone was given for periods up to 20 days there was no evidence of tachyphylaxis or delay in recovery time.

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