2020/05/12 by Federico Bocci, José N. Onuchic, Bocci, Federico +3 · 1 citation
Biochemistry, Genetics and Molecular Biology · #Developmental Biology and Gene Regulation #FOS: Biological sciences #Hippo pathway signaling and YAP/TAZ #Molecular Networks (q-bio.MN) #Tissues and Organs (q-bio.TO)
paper · pdf · doi:10.48550/arxiv.2005.05858
openalex publication_date 2020/05/12 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28
Notch signaling is an evolutionary conserved cell-cell communication pathway.\nBesides regulating cell-fate decisions at an individual cell level, Notch\nsignaling coordinates the emergent spatiotemporal patterning in a tissue\nthrough ligand-receptor interactions among transmembrane molecules of\nneighboring cells, as seen in embryonic development, angiogenesis, or wound\nhealing. Due to its ubiquitous nature, Notch signaling is also implicated in\nseveral aspects of cancer progression, including tumor angiogenesis, stemness\nof cancer cells and cellular invasion. Here, we review experimental and\ncomputational models to help understand the operating principles of cell\npatterning driven by Notch signaling. First, we discuss the basic mechanisms of\nspatial patterning via canonical lateral inhibition and lateral induction\nmechanisms, including examples from angiogenesis, inner ear development and\ncancer metastasis. Next, we analyze additional layers of complexity in the\nNotch pathway such as the effects of varying cell sizes and shapes,\nligand-receptor binding within the same cell, variable binding affinity of\ndifferent ligand/receptor subtypes, and filopodia. Finally, we discuss some\nrecent evidence of mechanosensitivity in the Notch pathway in driving\ncollective epithelial cell migration and cardiovascular morphogenesis.\n