The Association Between Quantitative Measures of Dementia and of Senile Change in the Cerebral Grey Matter of Elderly Subjects
1968/07/01 by G. Blessed, B. E. Tomlinson, Martin Roth · 37 citations
Medicine · Neuroscience · #Diet and metabolism studies #Memory and Neural Mechanisms #Dementia and Cognitive Impairment Research
paper · doi:10.1192/bjp.114.512.797
Abstract
The ageing of many populations in recent years has directed increasing attention to the social, medical and biological problems of senescence. The psychological changes associated with ageing occupy a central position in inquiries in this field. The expectation of mental disorder shows a steep increase with advancing chronological age, and beyond 75 years a large part of this increase is accounted for by disorders associated with degenerative changes in the central nervous system for which we lack remedies at the present time. Larsson et al . (1963) have estimated that the aggregate morbidity risk for these disorders up to the age of 70 is 0·4 per cent., up to age 75, 1·2 per cent. and up to age 80, 5 per cent. For higher ages estimates were probably less reliable, but the calculated risk up to the age of 90 was 5·2 per cent. In a survey of a random sample of elderly people aged 65 and over in the general population, Kay et al . (1964), found a total of 4·2 per cent. of elderly subjects to be suffering from senile dementia, 2·9 per cent. being mild cases. The condition is generally recognized as being a major cause of serious infirmity among the elderly in psychiatric, geriatric, general medical and community practice alike.
Cited by
- A New Clinical Scale for the Staging of Dementia
- Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature
- Six-Item Screener to Identify Cognitive Impairment Among Potential Subjects for Clinical Research
- DeepResBat: deep residual batch harmonization accounting for covariate distribution differences
- Quantitative 1H and 31P MRS of PCA extracts of postmortem Alzheimer's disease brain
- Lifetime risk and projected burden of dementia
- The measurement of everyday cognition (ECog): Scale development and psychometric properties.
- Assessment of the severely impaired patient: Description and validation of a new neuropsychological test battery.
- Clock-drawing: is it the ideal cognitive screening test?
- Controversial Past, Splendid Present, Unpredictable Future: A Brief Review of Alzheimer Disease History
- The COMFORTage project: study protocol for the integration of multiple sources towards personalised preventions at Ace Alzheimer Center Barcelona
- ALZHEIMER'S PRESENILE DEMENTIA, SENILE DEMENTIA OF ALZHEIMER TYPE AND DOWN'S SYNDROME IN MIDDLE AGE FORM AN AGE RELATED CONTINUUM OF PATHOLOGICAL CHANGES
- Influence of leisure activity on the incidence of Alzheimer's disease. [europepmc]
- Quantitative gait dysfunction and risk of cognitive decline and dementia. [europepmc]
- Frequency and course of mild cognitive impairment in a multiethnic community. [europepmc]
- The measurement of everyday cognition (ECog): scale development and psychometric properties. [europepmc]
- Consortium to Establish a Registry for Alzheimer's Disease (CERAD): the first twenty years. [europepmc]
- Mediterranean diet and mild cognitive impairment. [europepmc]
- Consistent neuroanatomical age-related volume differences across multiple samples. [europepmc]
- The diagnosis of young-onset dementia. [europepmc]
- Alzheimer disease. [europepmc]
- Amyloid precursor protein processing and Alzheimer's disease. [europepmc]
- Assessment of cognition using surveys and neuropsychological assessment: the Health and Retirement Study and the Aging, Demographics, and Memory Study. [europepmc]
- Overview and findings from the religious orders study. [europepmc]
- Correlation of Alzheimer disease neuropathologic changes with cognitive status: a review of the literature. [europepmc]
- Self-reported sleep and β-amyloid deposition in community-dwelling older adults. [europepmc]
- Diagnostic criteria for vascular cognitive disorders: a VASCOG statement. [europepmc]
- Using mice to model Alzheimer's dementia: an overview of the clinical disease and the preclinical behavioral changes in 10 mouse models. [europepmc]
- The interface between delirium and dementia in elderly adults. [europepmc]
- Amyloid-Beta and Phosphorylated Tau Accumulations Cause Abnormalities at Synapses of Alzheimer's disease Neurons. [europepmc]
- Alzheimer's disease: experimental models and reality. [europepmc]
- Alzheimer's Disease: Past, Present, and Future. [europepmc]
- Limbic-predominant age-related TDP-43 encephalopathy (LATE): consensus working group report. [europepmc]
- Alzheimer's disease: pathogenesis, diagnostics, and therapeutics. [europepmc]
- Brain reserve, cognitive reserve, compensation, and maintenance: operationalization, validity, and mechanisms of cognitive resilience. [europepmc]
- Profound loss of layer II entorhinal cortex neurons occurs in very mild Alzheimer's disease. [europepmc]
- Ectopic cell cycle proteins predict the sites of neuronal cell death in Alzheimer's disease brain. [europepmc]
Related