A New Depression Scale Designed to be Sensitive to Change
1979/04/01 by Stuart A. Montgomery, Stuart Montgomery, Marie Åsberg · 104 citations
Medicine · Psychology · Neuroscience · #Treatment of Major Depression #Mental Health Research Topics #Functional Brain Connectivity Studies
paper · doi:10.1192/bjp.134.4.382
Abstract
The construction of a depression rating scale designed to be particularly sensitive to treatment effects is described. Ratings of 54 English and 52 Swedish patients on a 65 item comprehensive psychopathology scale were used to identify the 17 most commonly occurring symptoms in primary depressive illness in the combined sample. Ratings on these 17 items for 64 patients participating in studies of four different antidepressant drugs were used to create a depression scale consisting of the 10 items which showed the largest changes with treatment and the highest correlation to overall change. The inner-rater reliability of the new depression scale was high. Scores on the scale correlated significantly with scores on a standard rating scale for depression, the Hamilton Rating Scale (HRS), indicating its validity as a general severity estimate. Its capacity to differentiate between responders and non-responders to antidepressant treatment was better than the HRS, indicating greater sensitivity to change. The practical and ethical implications in terms of smaller sample sizes in clinical trials are discussed.
Cited by
- Long term effectiveness of dialectical behavior therapy versus enhanced usual care for adolescents with self‐harming and suicidal behavior
- A longitudinal study of rumination and distraction in formerly depressed inpatients and community controls.
- The validity of the Hospital Anxiety and Depression Scale
- Assessment of mood: Guides for clinicians
- Single Treatment With MM120 (Lysergide) in Generalized Anxiety Disorder
- Detecting depression in Parkinson disease
- LSD microdosing in major depressive disorder: results from an open-label trial
- Perinatal Depression
- N-acetylcysteine as an adjunctive treatment for bipolar depression and major depressive disorder: a systematic review and meta-analysis of double-blind, randomized placebo-controlled trials
- Antidepressant medications in dementia: evidence and potential mechanisms of treatment-resistance
- Bedroom light exposure at night and obesity in individuals with bipolar disorder: A cross-sectional analysis of the APPLE cohort
- Comprehensive MRI assessment reveals subtle brain findings in non-hospitalized post-COVID patients with cognitive impairment
- Moderators of antidepressant augmentation versus switch in the OPTIMUM randomised controlled trial
- Psychiatric Morbidity in Adults with Hypopituitarism
- A meta-analysis of the problematic social media use and mental health
- Efficacy and safety of aticaprant, a kappa receptor antagonist, adjunctive to oral SSRI/SNRI antidepressant in major depressive disorder: results of a phase 2 randomized, double-blind, placebo-controlled study
- Cerebrospinal fluid cortisol and clinical disease progression in MCI and dementia of Alzheimer's type
- Reward circuitry predicts the effects of fMRI-guided accelerated prolonged iTBS in treatment-resistant depression
- Comprehensive transcriptome assessment in PBMCs of post-COVID patients at a median follow-up of 28 months after a mild COVID infection reveals upregulation of JAK/STAT signaling and a prolonged immune response
- A Voice-Enabled Virtual Patient System for Interactive Training in Standardized Clinical Assessment
- Aging faster: worry and rumination in late life are associated with greater brain age
- Climbing high: a mixed-methods feasibility study of climbing therapy for major depressive disorder in Ireland
- Psilocybin for treatment resistant depression in patients taking a concomitant SSRI medication
- A new approach to care planning in community mental health: the 9-step Collaborative Care Pathway (CCP-9) – Paper I
- Changes in EEG-derived entropy are associated with symptom improvement in major depressive disorder following electroconvulsive therapy
- Ketamine for treatment-resistant obsessive-compulsive disorder: Double-blind active-controlled crossover study
- Coping strategies in patients with acquired brain injury: relationships between coping, apathy, depression and lesion location
- A Framework for Advancing Mechanistic Neurobehavioral Biomarkers in Psychiatry
- Reliabilität und Validität des revidierten Beck-Depressionsinventars (BDI-II)
- A common symptom geometry of mood improvement under sertraline and placebo associated with distinct neural patterns
- Efficacy and Safety of Flexibly Dosed Esketamine Nasal Spray Plus a Newly Initiated Oral Antidepressant in Adult Patients with Treatment-Resistant Depression: A Randomized, Double-Blind, Multicenter, Active-Controlled Study Conducted in China and USA
- Up to speed: Birth cohort effects observed for speed of processing in older adults: Data from the Good Ageing in Skåne population study
- A review of depression and suicide risk assessment using speech analysis
- Role of theory of mind in emotional awareness and alexithymia: Implications for conceptualization and measurement
- Review on the Use of Brain Computer Interface Rehabilitation Methods for Treating Mental and Neurological Conditions
- Cognitive Behavioral Therapy to Sustain the Antidepressant Effects of Ketamine in Treatment-Resistant Depression: A Randomized Clinical Trial
- Effectiveness of Individual Cognitive-Behavioral Therapy and Predictors of Outcome in Adult Patients with Obsessive-Compulsive Disorder
- Emotion introspection and regulation in depression
- Cognitive outcomes following psilocybin-assisted therapy in treatment-resistant depression: A post-hoc analysis of a randomized, waitlist-controlled trial
- Low-Dose Buprenorphine Following Ketamine Treatment for Suicidal Ideation in Major Depressive Disorder: A Randomized, Double-Blind, Placebo-Controlled Trial
- Randomized Placebo-Controlled Adjunctive Study of an Extract of<i>Withania somnifera</i>for Cognitive Dysfunction in Bipolar Disorder
- Higher order thalamic nuclei resting network connectivity in early schizophrenia and major depressive disorder
- Structural abnormalities associated with poor outcome of a major depressive episode: The role of thalamus
- Clinical Significance and Remission in Treating Major Depressive Disorder: Parallels Between Related Outcome Constructs
- Media Use and Its Associations With Paranoia in Schizophrenia and Bipolar Disorder: Ecological Momentary Assessment
- Types of Media Use and their Associations with Paranoia: An Ecological Momentary Assessment Study
- Insights into neuroscience from the representative birth cohort samples of a multidisciplinary longitudinal study
- Ketamine and Esketamine augmentation for suicidal ideation: A randomized, double-blinded clinical trial
- Single-Dose Psilocybin for a Treatment-Resistant Episode of Major Depression
- Perceived stigma and self-stigma in young people at ultra-high risk for psychosis: Associations with identity-related, psychological and functional outcomes
- The short-term impact of music interventions on stress: Results of a multinational cluster-randomized trial using salivary cortisol and alpha-amylase assessments in care home residents with dementia
- Does isovaleric acid play a key role in the interaction between probiotics and antidepressants? A secondary analysis of a randomized clinical trial
- Network meta-analysis of the effectiveness of psychotherapies with or without medication for treating adult depression
- Higher <scp>CSF</scp> /serum <scp>free‐T4</scp> ratio is associated with improvement of quality of life during treatment with L‐thyroxine
- A double-blind, placebo-controlled, randomised withdrawal study of adjunctive brexpiprazole maintenance treatment for major depressive disorder
- The MADRS Pipeline: Supporting Depression Assessment in Clinical Trials
- Examining the effects of psilocybin-assisted psychotherapy on anhedonia in treatment-resistant depression
- Which aspects of anhedonia predict response to pharmacotherapy in major depressive disorder?
- Changes in Nighttime Sleep Duration and Their Association With Cognitive Decline and Dementia Risk
- Light Therapy for Patients With Bipolar Depression: Systematic Review and Meta-Analysis of Randomized Controlled Trials
- Blue-Light Therapy for Seasonal and Non-Seasonal Depression: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
- Predicting Relapse of Depressive Episodes During Maintenance Treatment: The Canadian Biomarker Integration Network in Depression (CAN-BIND) Wellness Monitoring in Major Depressive Disorder Study: Prédire la rechute d’épisodes dépressifs pendant le traitement d’entretien : Une étude de suivi du bien-être dans les troubles dépressifs majeurs du Réseau canadien d’intégration des biomarqueurs pour la dépression (CAN-BIND)
- Medically supervised ketogenic diet as an adjunctive treatment for moderate to severe depression: A pilot study
- A randomised controlled trial of dietary improvement for adults with major depression (the ‘SMILES’ trial)
- Randomized trial of ketamine masked by surgical anesthesia in patients with depression
- Crosswalk between HRSD and MADRS outcomes for rTMS in patients with depression
- Intranasal esketamine in treatment-resistant depression with and without comorbid borderline personality disorder: A multicenter real-world longitudinal study
- Intranasal esketamine for treatment-resistant depression: real-world effectiveness in electroconvulsive therapy non-responders
- Between “normality” and diagnosis: strains between the I and the Me in undiagnosed adolescents with ADHD symptoms
- Estimates of the minimal important difference to evaluate the clinical significance of antidepressants in the acute treatment of moderate-to-severe depression
- Declining efficacy in controlled trials of antidepressants: effects of placebo dropout
- Effects of daylight on sleep and circadian rhythms in patients with depression
- The influence of age at onset and duration of illness on long-term outcome in patients with obsessive-compulsive disorder: A report from the International College of Obsessive Compulsive Spectrum Disorders (ICOCS)
- One (effect) size does not fit at all: Interpreting clinical significance and effect sizes in depression treatment trials
- Vividness of mental imagery in Posttraumatic Stress Disorder (PTSD): The role of depression
- Precision Mental Health: Predicting Heterogeneous Treatment Effects for Depression through Data Integration
- Determinants of Nonspecific Response to Treatment in Randomized Controlled Trials of Major Depressive Disorder: A Narrative Review
- Durability of the benefit of vagus nerve stimulation in markedly treatment-resistant major depression: a RECOVER trial report
- "Mirror" Language AI Models of Depression are Criterion-Contaminated
- An evaluation of the quick inventory of depressive symptomatology and the hamilton rating scale for depression: a sequenced treatment alternatives to relieve depression trial report. [europepmc]
- Depression and risk for Alzheimer disease: systematic review, meta-analysis, and metaregression analysis. [europepmc]
- Impaired cognitive flexibility and motor inhibition in unaffected first-degree relatives of patients with obsessive-compulsive disorder. [europepmc]
- Depression rating scales in Parkinson's disease: critique and recommendations. [europepmc]
- Cognitive-behavioral therapy for adult anxiety disorders: a meta-analysis of randomized placebo-controlled trials. [europepmc]
- Diagnosis, management, and treatment of hepatitis C: an update. [europepmc]
- Effects of intravenous ketamine on explicit and implicit measures of suicidality in treatment-resistant depression. [europepmc]
- CSF concentrations of brain tryptophan and kynurenines during immune stimulation with IFN-alpha: relationship to CNS immune responses and depression. [europepmc]
- Rapid resolution of suicidal ideation after a single infusion of an N-methyl-D-aspartate antagonist in patients with treatment-resistant major depressive disorder. [europepmc]
- Whole brain resting-state analysis reveals decreased functional connectivity in major depression. [europepmc]
- Depression symptom dimensions as predictors of antidepressant treatment outcome: replicable evidence for interest-activity symptoms. [europepmc]
- Major depressive disorder is associated with broad impairments on neuropsychological measures of executive function: a meta-analysis and review. [europepmc]
- Rapid and longer-term antidepressant effects of repeated ketamine infusions in treatment-resistant major depression. [europepmc]
- Dopaminergic mechanisms of reduced basal ganglia responses to hedonic reward during interferon alfa administration. [europepmc]
- Clinical phenotypes of psychosis in the Bipolar-Schizophrenia Network on Intermediate Phenotypes (B-SNIP). [europepmc]
- Antidepressant efficacy of ketamine in treatment-resistant major depression: a two-site randomized controlled trial. [europepmc]
- Large-Scale Network Dysfunction in Major Depressive Disorder: A Meta-analysis of Resting-State Functional Connectivity. [europepmc]
- Single-dose infusion ketamine and non-ketamine N-methyl-d-aspartate receptor antagonists for unipolar and bipolar depression: a meta-analysis of efficacy, safety and time trajectories. [europepmc]
- A randomised controlled trial of dietary improvement for adults with major depression (the 'SMILES' trial). [europepmc]
- Efficacy and Safety of Intranasal Esketamine Adjunctive to Oral Antidepressant Therapy in Treatment-Resistant Depression: A Randomized Clinical Trial. [europepmc]
- Double-blind, placebo-controlled, dose-ranging trial of intravenous ketamine as adjunctive therapy in treatment-resistant depression (TRD). [europepmc]
- The Effects of Dietary Improvement on Symptoms of Depression and Anxiety: A Meta-Analysis of Randomized Controlled Trials. [europepmc]
- Lower synaptic density is associated with depression severity and network alterations. [europepmc]
- The clinical characterization of the adult patient with depression aimed at personalization of management. [europepmc]
- Single-Dose Psilocybin Treatment for Major Depressive Disorder: A Randomized Clinical Trial. [europepmc]
Related