Exploitation of the genomic double-strand breaks to reduce the reproductive power of microorganisms

2015/05/29 by Giandomenico Sassi, Sassi, Giandomenico, Nicola Sassi +1
Biochemistry, Genetics and Molecular Biology · Environmental Science · #Bacterial Genetics and Biotechnology #Bacteriophages and microbial interactions #Biological Physics (physics.bio-ph) #Biomolecules (q-bio.BM) #FOS: Biological sciences #FOS: Physical sciences #Genomics (q-bio.GN) #Genomics and Chromatin Dynamics

paper · pdf · doi:10.48550/arxiv.1505.08014

openalex publication_date 2015/05/29 · openalex created_date 2016/06/24 · openalex updated_date 2026/07/28

Abstract

It is shown how to take advantage of the frequent occurrence of double-strand breaks in the genome of prokaryotic cells, in order to reduce their high efficient reproductive capability. The analysis examines the physical status of the free ends of each break and considers how this status can interfere with an external physical apparatus, with the aim of undermining the repair processes. We indicate the biological consequences of this interaction and we give an approximate evaluation of the topological and dynamical effects that arise on the genomic material involved. The overall result suggests a significant reduction of the dynamics of the repair.

Citations

• Theory of high-force DNA stretching and overstretching

Related

• Mechanisms and Consequences of Double‐Strand DNA Break Formation in Chromatin
• Suppression of plastid-to-nucleus gene transfer by DNA double-strand break repair
• Double-Strand Break Clustering: An Economical and Effective Strategy for DNA Repair
• Genoautotomy (Genome 'Self-Injury') in Eukaryotic Cells: A Cellular Defence Response to Genotoxic Stress
• MISMATCH REPAIR IN REPLICATION FIDELITY, GENETIC RECOMBINATION, AND CANCER BIOLOGY