2025/09/24 by Veronica C. Ciliberto, Maya Solis, Carolyne Chepkosgei +2
Neuroscience · Biochemistry, Genetics and Molecular Biology · #Neurobiology and Insect Physiology Research #Zebrafish Biomedical Research Applications #Neuroscience and Neuropharmacology Research
paper · doi:10.17912/micropub.biology.001871
heterozygous flies with reduced brain ecdysone exhibit accelerated, aging-related declines in climbing performance in a stimulus-induced negative geotaxis assay, without affecting basal activity. These findings implicate ecdysone signaling as a critical regulator of aging-sensitive motor function and suggest a conserved steroid pathway contributing to AMI across species.