Alternative Healthy Eating Index 2010, Dietary Inflammatory Index and risk of mortality: results from the Whitehall II cohort study and meta-analysis of previous Dietary Inflammatory Index and mortality studies
2017/08/14 by Nitin Shivappa, James R. Hebert, James R. Hébert +3 · 97 citations
Medicine · #Body mass index #Cohort #Cohort study #Confidence interval #Demography #Diet and metabolism studies #Hazard ratio #Internal medicine #Medicine #Meta-analysis #Nutritional Studies and Diet #Obesity, Physical Activity, Diet #Proportional hazards model
paper · pdf · doi:10.1017/s0007114517001908
published in British Journal Of Nutrition 118(3), 210-221 (Cambridge University Press)
openalex publication_date 2017/08/14 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/04
Abstract
We aimed to examine the association between the Alternative Healthy Eating Index updated in 2010 (AHEI-2010), the Dietary Inflammatory Index (DIITM) and risk of mortality in the Whitehall II study. We also conducted a meta-analysis on the DII-based results from previous studies to summarise the overall evidence. Data on dietary behaviour assessed by self-administered repeated FFQ and on mortality status were available for 7627 participants from the Whitehall II cohort. Cox proportional hazards regression models were performed to assess the association between cumulative average of AHEI-2010 and DII scores and mortality risk. During 22 years of follow-up, 1001 participants died (450 from cancer, 264 from CVD). Both AHEI-2010 (mean=48·7 (sd 10·0)) and DII (mean=0·37 (sd 1·41)) were associated with all-cause mortality. The fully adjusted hazard ratio (HR) per sd, were 0·82; 95 % CI 0·76, 0·88 for AHEI-2010 and 1·18; 95 % CI 1·08, 1·29 for DII. Significant associations were also observed with cardiovascular and cancer mortality risk. For DII, a meta-analysis (using fixed effects) from this and four previous studies showed a positive association of DII score with all-cause (HR=1·04; 95 % CI 1·03, 1·05, 28 891deaths), cardiovascular (HR=1·05; 95 % CI 1·03, 1·07, 10 424 deaths) and cancer mortality (HR=1·05; 95 % CI 1·03, 1·07, n 8269).The present study confirms the validity to assess overall diet through AHEI-2010 and DII in the Whitehall II cohort and highlights the importance of considering diet indices related to inflammation when evaluating all-cause, cardiovascular and cancer mortality risk.
Cited by
- Diet Quality and Dementia Risk in Older Adults With Alzheimer Pathology
- Dietary Inflammatory Index and Cardiovascular Risk and Mortality-A Meta-Analysis. [europepmc]
- Association of Long-Term Diet Quality with Hippocampal Volume: Longitudinal Cohort Study. [europepmc]
- Perspective: The Dietary Inflammatory Index (DII)-Lessons Learned, Improvements Made, and Future Directions. [europepmc]
- Cultural Differences in Diet and Determinants of Diet Quality in Switzerland: Results from the National Nutrition Survey menuCH. [europepmc]
- Assessment of Diet Quality in Chilean Urban Population through the Alternate Healthy Eating Index 2010: A Cross-Sectional Study. [europepmc]
- Diet and Chronic Diseases: Is There a Mediating Effect of Inflammation? [europepmc]
- Associations between Dietary Inflammatory Index Scores and Inflammatory Biomarkers among Older Adults in the Lothian Birth Cohort 1936 Study. [europepmc]
- Adherence to the Healthy Eating Index-2015 and Other Dietary Patterns May Reduce Risk of Cardiovascular Disease, Cardiovascular Mortality, and All-Cause Mortality. [europepmc]
- Diet quality as a predictor of cardiometabolic disease-free life expectancy: the Whitehall II cohort study. [europepmc]
- Impact of Intensive Lifestyle Treatment (Diet Plus Exercise) on Endothelial and Vascular Function, Arterial Stiffness and Blood Pressure in Stage 1 Hypertension: Results of the HINTreat Randomized Controlled Trial. [europepmc]
- Dietary inflammatory index and cardiovascular risk and mortality: A meta-analysis of cohort studies. [europepmc]
- Association of Dietary Patterns and Type-2 Diabetes Mellitus in Metabolically Homogeneous Subgroups in the KORA FF4 Study. [europepmc]
- Defining diet quality: a synthesis of dietary quality metrics and their validity for the double burden of malnutrition. [europepmc]
- The association between inflammatory potential of diet and disease activity: results from a cross-sectional study in patients with inflammatory bowel disease. [europepmc]
- Association of dietary inflammatory potential with cardiometabolic risk factors and diseases: a systematic review and dose-response meta-analysis of observational studies. [europepmc]
- Dietary Inflammatory Index and Risk of Asthenozoospermia: A Hospital-Based Case-Controlled Study in China. [europepmc]
- Evaluation of Dietary Patterns and All-Cause Mortality: A Systematic Review. [europepmc]
- Anti-inflammatory diet consumption reduced fatty liver indices. [europepmc]
- Effectiveness of Web-Based Personalized Nutrition Advice for Adults Using the eNutri Web App: Evidence From the EatWellUK Randomized Controlled Trial. [europepmc]
- Associations of dietary and lifestyle inflammation scores with mortality due to CVD, cancer, and all causes among Black and White American men and women. [europepmc]
- Maternal Dietary Inflammatory Index during Pregnancy Is Associated with Perinatal Outcomes: Results from the IMPACT BCN Trial. [europepmc]
- Associations Between Late Pregnancy Dietary Inflammatory Index (DII) and Offspring Bone Mass: A Meta-Analysis of the Southampton Women's Survey (SWS) and the Avon Longitudinal Study of Parents and Children (ALSPAC). [europepmc]
- Higher dietary inflammatory index is associated with increased all-cause mortality in adults with chronic kidney disease. [europepmc]
- Dietary Inflammatory Index and Mortality from All Causes, Cardiovascular Disease, and Cancer: A Prospective Study. [europepmc]
- Global dietary quality in 185 countries from 1990 to 2018 show wide differences by nation, age, education, and urbanicity. [europepmc]
Related