2006/07/20 by Naoki Oiso, Katsuya Watanabe, Akira Kawada · 4 citations
Medicine · #Autoimmune and Inflammatory Disorders #Tumors and Oncological Cases #Histiocytic Disorders and Treatments
paper · pdf · doi:10.1111/j.1365-2141.2006.06222.x
We present the case of a 29-year-old healthy woman as a donor for peripheral blood stem cell harvest with a complication of granulocyte colony-stimulating factor (G-CSF)-induced Sweet syndrome. Four days after commencing G-CSF 10 μg/kg/d, the donor developed tender, exudative erythematous plaques on the nape of the neck, trunk and upper limbs and felt general fatigue. A biopsy specimen showed dense neutrophilic infiltrates in superficial dermis with scattered lymphocytes and histiocytes. After cessation of G-CSF, the donor was treated with oral prednisolone 30 mg for 3 days, 20 mg for 2 days and 10 mg for 2 days, with satisfactory improvement. Cases of G-CSF-induced Sweet syndrome have been described as a complication of haematological malignancies. This is the first case to be reported in a healthy person. Sweet syndrome is characterised by peripheral neutrophilic leucocytosis and acute painful papules, plaques or nodules with histological findings of dense neutrophilic infiltrates in the superficial dermis. Elevated levels of G-CSF have been shown in patients with the active phase of Sweet syndrome. G-CSF is therefore believed to be involved in the development of this syndrome. Haematologists and dermatologists should be aware that G-CSF-induced Sweet syndrome can develop in healthy donors.