Haematologic manifestations of the human immune deficiency virus (HIV)

1987/06/01 by Leonard I. Zon, Charles Arkin, Charles F. Arkin +1 · 20 citations
Immunology and Microbiology · Medicine · #HIV Research and Treatment #HIV-related health complications and treatments #HIV/AIDS Research and Interventions #Human immunodeficiency virus (HIV) #Immune system #Immunology #Medicine #Virology #Virus

paper · doi:10.1111/j.1365-2141.1987.tb01307.x

openalex publication_date 1987/06/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01

Abstract

A variety of haematologic abnormalities are associated with infection by HIV, the human retrovirus that is the primary aetiologic agent of the acquired immunodeficiency syndrome (AIDS). We have reviewed the haematologic findings in well-characterized cohorts of patients with AIDS, AIDS-related complex (ARC) and asymptomatic homosexual men at risk for this retrovirus. Anaemia, granulocytopenia and thrombocytopenia were found in increasing prevalence according to the severity of clinical disease associated with retroviral infection. Bone marrow aspirations and biopsies revealed frequent hypercellularity, dysplasia, plasmacytosis and lymphoid infiltrates. These marrow morphologic findings were strongly associated with anaemia and granulocytopenia. Review of transfusion records of patients with HIV antibodies revealed a 21% prevalence of a positive direct antiglobulin test. The pathophysiology of the observed haematologic abnormalities may involve direct retroviral infection of bone marrow progenitors, abnormal regulation of haematopoiesis and/or autoimmune phenomena.

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