2016/08/24 by Amani A. Alobaidi, Bo Sun, Alobaidi, Amani A. +1
Biochemistry, Genetics and Molecular Biology · Engineering · Medicine · #3D Printing in Biomedical Research #Cancer Cells and Metastasis #Cell Behavior (q-bio.CB) #Cellular Mechanics and Interactions #FOS: Biological sciences #Tissues and Organs (q-bio.TO)
paper · pdf · doi:10.48550/arxiv.1608.06723
openalex publication_date 2016/08/24 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28
Multicellular migration and pattern formation play important roles in developmental biology, cancer metastasis and wound healing. To understand the collective cell dynamics in three dimensional extracellular matrix (ECM), we have developed a simple and mechanical-based strategy, Diskoid In Geometrically Micropatterned ECM (DIGME). DIGME allows easy engineering of the shape of 3-D tissue organoid, the mesoscale ECM heterogeneity, and the fiber alignment of collagen-based ECM all at the same time. We have employed DIGME to study the collective cancer invasion and find that DIGME provides a powerful tool to probe three dimensional dynamics of tumor organoid in patterned microenvironment.