Metagenome assembly of high-fidelity long reads with hifiasm-meta

2021/10/16 by Feng, Xiaowen, Cheng, Haoyu, Portik, Daniel +1 · 8 citations
#FOS: Biological sciences #Genomics (q-bio.GN)

paper · doi:10.48550/arxiv.2110.08457

Abstract

Current metagenome assemblers developed for short sequence reads or noisy long readswere not optimized for accurate long reads. Here we describe hifiasm-meta, a new metagenome assembler that exploits the high accuracy of recent data. Evaluated on seven empirical datasets, hifiasm-meta reconstructed tens to hundreds of complete circular bacterial genomes per dataset, consistently outperforming other metagenome assemblers.

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