TNF-α/NF-κB/Snail pathway in cancer cell migration and invasion
2010/01/19 by Y Wu, Yadi Wu, B P Zhou +1 · 33 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #NF-κB Signaling Pathways #Inflammatory mediators and NSAID effects #Cytokine Signaling Pathways and Interactions
paper · pdf · doi:10.1038/sj.bjc.6605530
Abstract
Tumour necrosis factor-alpha (TNF-alpha) is an important inflammatory factor that acts as a master switch in establishing an intricate link between inflammation and cancer. A wide variety of evidence has pointed to a critical role of TNF-alpha in tumour proliferation, migration, invasion and angiogenesis. The function of TNF-alpha as a key regulator of the tumour microenvironment is well recognised. We will emphasise the contribution of TNF-alpha and the nuclear factor-kappaB pathway on tumour cell invasion and metastasis. Understanding the mechanisms underlying inflammation-mediated metastasis will reveal new therapeutic targets for cancer prevention and treatment.
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