2017/04/27 by Taichi Haruna, Haruna, Taichi
Biochemistry, Genetics and Molecular Biology · #Adaptation and Self-Organizing Systems (nlin.AO) #Bioinformatics and Genomic Networks #FOS: Biological sciences #FOS: Physical sciences #Gene Regulatory Network Analysis #Microbial Metabolic Engineering and Bioproduction #Molecular Networks (q-bio.MN)
paper · pdf · doi:10.48550/arxiv.1704.08586
openalex publication_date 2017/04/27 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28
We propose new activity-dependent adaptive Boolean networks inspired by the cis-regulatory mechanism in gene regulatory networks. We analytically show that our model can be solved for stationary in-degree distribution for a wide class of update rules by employing the annealed approximation of Boolean network dynamics and that evolved Boolean networks have a preassigned average sensitivity that can be set independently of update rules if certain conditions are satisfied. In particular, when it is set to 1, our theory predicts that the proposed network rewiring algorithm drives Boolean networks towards criticality. We verify that these analytic results agree well with numerical simulations for four representative update rules. We also discuss the relationship between sensitivity of update rules and stationary in-degree distributions and compare it with that in real-world gene regulatory networks.