Synthesis of novel 1,2,3-triazolic compounds derived from natural product, by the copper(I)-catalyzed alkyne-azide (CuAAC) cycloaddition

2020/04/18 by El Mestafa El Hadrami, Fatima El Aroussi, EL Hadrami, E. M. +7
Chemistry · #1 #2 #3-triazole #Click Chemistry and Applications #carvacrol #click chemistry #eugenol #thymol

paper · doi:10.48317/imist.prsm/morjchem-v8i3.20510

openalex publication_date 2020/04/18 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/01

Abstract

A series of novel 1,2,3-triazolic compounds derived from natural products (thymol, carvacrol and eugenol) was synthesized by the copper(I)-catalyzed alkyne-azide (CuAAC) cycloaddition between the corresponding propargyl ethers of each natural product and a variety of azides. The reaction conducted with catalytic amount of copper (II) sulfate and sodium ascorbate affording desired products in good yields and their structures were confirmed by spectral techniques such as 1H NMR, 13C NMR and high resolution mass spectrometry ( HRMS).

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